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Profiling donepezil template into multipotent hybrids with antioxidant properties.

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第一作者： Eva,Mezeiova

第一单位： a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;b National Institute of Mental Health , Klecany , Czech Republic.

作者： Eva,Mezeiova ^[1] ; Katarina,Spilovska ^[2] ; Eugenie,Nepovimova ^[3] ; Lukas,Gorecki ^[4] ; Ondrej,Soukup ^[1] ; Rafael,Dolezal ^[5] ; David,Malinak ^[6] ; Jana,Janockova ^[5] ; Daniel,Jun ^[4] ; Kamil,Kuca ^[6] ; Jan,Korabecny ^[4]

作者单位： a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;b National Institute of Mental Health , Klecany , Czech Republic. ^[1] a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;b National Institute of Mental Health , Klecany , Czech Republic.;d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic. ^[2] a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic.;d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic. ^[3] a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;c Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences , Hradec Kralove , Czech Republic. ^[4] a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic. ^[5] a Biomedical Research Centre, University Hospital Hradec Kralove , Hradec Kralove , Czech Republic.;d Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic. ^[6]

关键词 Acetylcholinesterase Alzheimer’s disease donepezil multi-target directed ligands oxidative stress