Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.-论文-万方医学网

作者： Mary Courtney,Moore ^[1] ; David E,Kelley ^[2] ; Raul C,Camacho ^[2] ; Peter,Zafian ^[2] ; Tian,Ye ^[2] ; Songnian,Lin ^[2] ; Niels C,Kaarsholm ^[2] ; Ravi,Nargund ^[2] ; Terri M,Kelly ^[2] ; Margaret,Van Heek ^[2] ; Stephen F,Previs ^[2] ; Christopher,Moyes ^[2] ; Marta S,Smith ^[3] ; Ben,Farmer ^[4] ; Phil,Williams ^[5] ; Alan D,Cherrington ^[4]

作者单位： Department of Molecular Biology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN genie.moore@vanderbilt.edu.;Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN. ^[1] Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ. ^[2] Department of Molecular Biology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN. ^[3] Department of Molecular Biology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN.;Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN. ^[4] Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN.;Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN. ^[5]

主题词动物(Animals);血糖(Blood Glucose);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物评价, 临床前(Drug Evaluation, Preclinical);药物, 临床试用(Drugs, Investigational);能量代谢(Energy Metabolism);糖原异生(Gluconeogenesis);葡萄糖钳制技术(Glucose Clamp Technique);糖基化(Glycosylation);人类(Humans);高血糖症(Hyperglycemia);低血糖症(Hypoglycemia);降血糖药(Hypoglycemic Agents);输注, 静脉内(Infusions, Intravenous);肝(Liver);男(雄)性(Male);代谢清除率(Metabolic Clearance Rate);随机分配(Random Allocation);生长抑素(Somatostatin)

DOI 10.2337/db18-0099

PMID 29540491

发布时间 2024-09-22

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Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.

Diabetes

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Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.

Diabetes

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Diabetes

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