Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures.

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作者： Assem,Barakat ^[1] ; Abdullah M,Al-Majid ^[2] ; Bander M,Al-Qahtany ^[3] ; M,Ali ^[3] ; Mohamed,Teleb ^[3] ; Mohamed H,Al-Agamy ^[4] ; Sehrish,Naz ^[5] ; Zaheer,Ul-Haq ^[6]

作者单位： Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia. ambarakat@ksu.edu.sa. ^[1] Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, 21321, Alexandria, Egypt. ambarakat@ksu.edu.sa. ^[2] Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia. ^[3] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. ^[4] Microbiology and Immunology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. ^[5] Division of Microbiology, Pharmaceutics Department, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh, 11451, Saudi Arabia. ^[6] Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75210, Pakistan. ^[7]

关键词 Antifungal activity Antimicrobial activity Dimedone Inhibition mechanism prediction Pyrazole Structure activity relationship

DOI 10.1186/s13065-018-0399-0

PMID 29541952

发布时间 2020-10-01

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