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首页> Antiviral research> Improved immune response against HIV-1 Env antigen by enhancing EEV production via a K151E mutation in the A34R gene of replication-competent vaccinia virus Tiantan.

Improved immune response against HIV-1 Env antigen by enhancing EEV production via a K151E mutation in the A34R gene of replication-competent vaccinia virus Tiantan.

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作者： Jie,Yu ^[1] ; Yaoming,Li ^[2] ; Maohua,Zhong ^[3] ; Jingyi,Yang ^[2] ; Dihan,Zhou ^[2] ; Bali,Zhao ^[2] ; Yuan,Cao ^[2] ; Hu,Yan ^[2] ; Ejuan,Zhang ^[2] ; Yi,Yang ^[2] ; Zhengshan,Feng ^[2] ; Xiuwen,Qi ^[2] ; Huimin,Yan ^[4]

作者单位： Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China. ^[1] Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China. ^[2] Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China. Electronic address: zmh@wh.iov.cn. ^[3] Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: hmyan@wh.iov.cn. ^[4]

关键词 Extracellular enveloped virus (EEV) formation Gene mutation HIV-1 Immune response Vaccine

主题词艾滋病疫苗(AIDS Vaccines);动物(Animals);抗体, 中和(Antibodies, Neutralizing);药物载体(Drug Carriers);糖蛋白类(Glycoproteins);HIV抗体(HIV Antibodies);HIV-1(HIV-1);小鼠(Mice);突变, 误义(Mutation, Missense);T淋巴细胞(T-Lymphocytes);痘苗病毒(Vaccinia virus);病毒包膜蛋白质类(Viral Envelope Proteins);病毒释放(Virus Release);env基因产物, 人免疫缺陷病毒(env Gene Products, Human Immunodeficiency Virus)

DOI 10.1016/j.antiviral.2018.03.004

PMID 29550516

发布时间 2019-06-03

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Antiviral research

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