Clinical pharmacodynamic/exposure characterisation of the multikinase inhibitor ilorasertib (ABT-348) in a phase 1 dose-escalation trial.

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第一作者： Michael L,Maitland

第一单位： Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Comprehensive Cancer Center, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Inova Schar Cancer Institute, Inova Center for Personalized Health, and Virginia Commonwealth University, 3225 Gallows Road, Falls Church, VA, 22037, USA. Michael.Maitland@inova.org.

作者： Michael L,Maitland ^[1] ; Sarina,Piha-Paul ^[2] ; Gerald,Falchook ^[3] ; Razelle,Kurzrock ^[4] ; Ly,Nguyen ^[2] ; Linda,Janisch ^[5] ; Sanja,Karovic ^[6] ; Mark,McKee ^[7] ; Elizabeth,Hoening ^[7] ; Shekman,Wong ^[7] ; Wijith,Munasinghe ^[7] ; Joann,Palma ^[7] ; Cherrie,Donawho ^[7] ; Guinan K,Lian ^[7] ; Peter,Ansell ^[7] ; Mark J,Ratain ^[8] ; David,Hong ^[2]

作者单位： Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Comprehensive Cancer Center, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. Michael.Maitland@inova.org.;Inova Schar Cancer Institute, Inova Center for Personalized Health, and Virginia Commonwealth University, 3225 Gallows Road, Falls Church, VA, 22037, USA. Michael.Maitland@inova.org. ^[1] Department of Investigational Cancer Therapeutics, The University of Texas, MD Anderson Cancer Center, 1400 Holcombe Boulevard, Unit 455, Faculty Center 8th Floor, Houston, TX, 77030, USA. ^[2] Sarah Cannon Research Institute at HealthONE, Drug Development, 1800 N Williams Street Suite 300, Denver, CO, 80218, USA. ^[3] Center for Personalized Cancer Therapy, Moores Cancer Center, The University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA, 92093, USA. ^[4] Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. ^[5] Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.;Inova Schar Cancer Institute, Inova Center for Personalized Health, and Virginia Commonwealth University, 3225 Gallows Road, Falls Church, VA, 22037, USA. ^[6] AbbVie Inc., 1 N Waukegan Road, North Chicago, IL, 60064, USA. ^[7] Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.;Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.;Comprehensive Cancer Center, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. ^[8]