首页> Nature medicine> A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

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第一作者： Neville K,Kisalu

第一单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

作者： Neville K,Kisalu ^[1] ; Azza H,Idris ^[1] ; Connor,Weidle ^[2] ; Yevel,Flores-Garcia ^[3] ; Barbara J,Flynn ^[1] ; Brandon K,Sack ^[4] ; Sean,Murphy ^[4] ; Arne,Schön ^[5] ; Ernesto,Freire ^[5] ; Joseph R,Francica ^[1] ; Alex B,Miller ^[6] ; Jason,Gregory ^[3] ; Sandra,March ^[6] ; Hua-Xin,Liao ^[7] ; Barton F,Haynes ^[8] ; Kevin,Wiehe ^[9] ; Ashley M,Trama ^[7] ; Kevin O,Saunders ^[10] ; Morgan A,Gladden ^[7] ; Anthony,Monroe ^[7] ; Mattia,Bonsignori ^[9] ; Masaru,Kanekiyo ^[1] ; Adam K,Wheatley ^[1] ; Adrian B,McDermott ^[1] ; S Katie,Farney ^[1] ; Gwo-Yu,Chuang ^[1] ; Baoshan,Zhang ^[1] ; Natasha,Kc ^[11] ; Sumana,Chakravarty ^[11] ; Peter D,Kwong ^[1] ; Photini,Sinnis ^[3] ; Sangeeta N,Bhatia ^[6] ; Stefan H I,Kappe ^[4] ; B Kim Lee,Sim ^[11] ; Stephen L,Hoffman ^[11] ; Fidel,Zavala ^[3] ; Marie,Pancera ^[2] ; Robert A,Seder ^[1]

作者单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ^[1] Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. ^[2] Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. ^[3] Seattle Biomedical Research Institute, Seattle, Washington, USA. ^[4] Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA. ^[5] Division of Health Sciences and Technology, Institute for Medical Engineering and Science, and The Broad Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. ^[6] Duke Human Vaccine Institute, Durham, North Carolina, USA. ^[7] Duke Human Vaccine Institute, Durham, North Carolina, USA.;Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.;Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA. ^[8] Duke Human Vaccine Institute, Durham, North Carolina, USA.;Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. ^[9] Duke Human Vaccine Institute, Durham, North Carolina, USA.;Department of Surgery, Duke University School of Medicine, Duke University Medical Center, Durham, North Carolina, USA. ^[10] Sanaria Inc., Rockville, Maryland, USA. ^[11]

医学主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗体, 原虫(Antibodies, Protozoan);人类(Humans);疟疾(Malaria);疟疾疫苗(Malaria Vaccines);小鼠(Mice);寄生虫(Parasites);恶性疟原虫(Plasmodium falciparum);原虫蛋白质类(Protozoan Proteins)

DOI 10.1038/nm.4512

PMID 29554083

发布时间 2025-05-30

基金项目

R01 AI132359/AI/NIAID NIH HHS/United States P01 GM056550/GM/NIGMS NIH HHS/United States S10 OD021832/OD/NIH HHS/United States ZIA AI005107-07/Intramural NIH HHS/United States S10 OD018164/OD/NIH HHS/United States

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