Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors.

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第一作者： Daniela,Hulcová

第一单位： ADINACO Research Group, Department of Pharmacognosy, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz.

作者： Daniela,Hulcová ^[1] ; Kateřina,Breiterová ^[2] ; Tomáš,Siatka ^[3] ; Kamila,Klímová ^[4] ; Lara,Davani ^[5] ; Marcela,Šafratová ^[6] ; Anna,Hošťálková ^[7] ; Angela,De Simone ^[8] ; Vincenza,Andrisano ^[9] ; Lucie,Cahlíková ^[10]

作者单位： ADINACO Research Group, Department of Pharmacognosy, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz. ^[1] Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz. ^[2] Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. breiterk@faf.cuni.cz. ^[3] ADINACO Research Group, Department of Pharmacognosy, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. siatka@faf.cuni.cz. ^[4] Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. kklimova000@gmail.com. ^[5] Department for Life Quality Studies, University of Bologna, 47921 Rimini, Italy. lorisdavani@libero.it. ^[6] ADINACO Research Group, Department of Pharmacognosy, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. safratom@faf.cuni.cz. ^[7] Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. hosta4aa@faf.cuni.cz. ^[8] Department for Life Quality Studies, University of Bologna, 47921 Rimini, Italy. angela.desimone2@unibo.it. ^[9] Department for Life Quality Studies, University of Bologna, 47921 Rimini, Italy. vincenza.andrisano@unibo.it. ^[10] Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz. ^[11]

关键词 9-O-demethylhomolycorine Alzheimer’s disease Amaryllidaceae alkaloids caranine glycogen synthase kinase-3β masonine

主题词石蒜科生物碱类(Amaryllidaceae Alkaloids);药物评价, 临床前(Drug Evaluation, Preclinical);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);蛋白激酶抑制剂(Protein Kinase Inhibitors)

DOI 10.3390/molecules23040719

PMID 29561817

发布时间 2018-12-07

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