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Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.

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第一作者： Guillermo,Senisterra

第一单位： 1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.

作者： Guillermo,Senisterra ^[1] ; Hugh Y,Zhu ^[2] ; Xiao,Luo ^[2] ; Hailong,Zhang ^[2] ; Guoliang,Xun ^[2] ; Chunliang,Lu ^[2] ; Wen,Xiao ^[2] ; Taraneh,Hajian ^[1] ; Peter,Loppnau ^[1] ; Irene,Chau ^[1] ; Fengling,Li ^[1] ; Abdellah,Allali-Hassani ^[1] ; Peter,Atadja ^[2] ; Counde,Oyang ^[2] ; En,Li ^[2] ; Peter J,Brown ^[1] ; Cheryl H,Arrowsmith ^[3] ; Kehao,Zhao ^[4] ; Zhengtian,Yu ^[2] ; Masoud,Vedadi ^[5]

作者单位： 1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada. ^[1] 2 Novartis Institutes for BioMedical Research (China), Pudong, Shanghai, China. ^[2] 1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.;3 Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. ^[3] 2 Novartis Institutes for BioMedical Research (China), Pudong, Shanghai, China.;4 School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China. ^[4] 1 Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.;5 Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. ^[5]

关键词 DNMT1 UHRF1 cancer and cancer drugs tandem tudor domain