首页> Genetics in medicine : official journal of the American College of Medical Genetics> Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.

Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study.

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第一作者： Fabio,Girardi

第一单位： Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

作者： Fabio,Girardi ^[1] ; Daniel R,Barnes ^[1] ; Daniel,Barrowdale ^[1] ; Debra,Frost ^[1] ; Angela F,Brady ^[2] ; Claire,Miller ^[3] ; Alex,Henderson ^[4] ; Alan,Donaldson ^[5] ; Alex,Murray ^[6] ; Carole,Brewer ^[7] ; Caroline,Pottinger ^[8] ; D Gareth,Evans ^[9] ; Diana,Eccles ^[10] ; EMBRACE ^[11] ; Fiona,Lalloo ^[12] ; Helen,Gregory ^[13] ; Jackie,Cook ^[14] ; Jacqueline,Eason ^[15] ; Julian,Adlard ^[16] ; Julian,Barwell ^[17] ; Kai Ren,Ong ^[18] ; Lisa,Walker ^[19] ; Louise,Izatt ^[20] ; Lucy E,Side ^[21] ; M John,Kennedy ^[22] ; Marc,Tischkowitz ^[23] ; Mark T,Rogers ^[24] ; Mary E,Porteous ^[25] ; Patrick J,Morrison ^[26] ; Ros,Eeles ^[27] ; Rosemarie,Davidson ^[28] ; Katie,Snape ^[29] ; Douglas F,Easton ^[30] ; Antonis C,Antoniou

作者单位： Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ^[1] North West Thames Regional Genetics Service, Northwick Park Hospital, London North West Healthcare NHS Trust, Harrow, UK. ^[2] Cheshire and Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, UK. ^[3] Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK. ^[4] Clinical Genetics Department, St Michael's Hospital, Bristol, UK. ^[5] All Wales Medical Genetics Services, Singleton Hospital, Swansea, UK. ^[6] Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, UK. ^[7] All Wales Medical Genetics Service, Glan Clwyd Hospital, Rhyl, UK. ^[8] Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre, Division of Evolution and Genomic Science, Manchester University, Manchester Universities NHS Foundation Trust, Manchester, UK. ^[9] University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK. ^[10] Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre, Manchester Universities NHS Foundation Trust, Manchester, UK. ^[11] North of Scotland Regional Genetics Service, NHS Grampian & University of Aberdeen, Foresterhill, Aberdeen, UK. ^[12] Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK. ^[13] Nottingham Clinical Genetics Service, Nottingham University Hospitals NHS Trust, Nottingham, UK. ^[14] Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. ^[15] Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. ^[16] West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK. ^[17] Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK. ^[18] Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK. ^[19] North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK. ^[20] Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Ireland. ^[21] Department of Medical Genetics, University of Cambridge, Cambridge, UK. ^[22] All Wales Medical Genetics Services, University Hospital of Wales, Cardiff, UK. ^[23] South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK. ^[24] Centre for Cancer Research and Cell Biology, Queens University of Belfast, Belfast, UK. ^[25] Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. ^[26] Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK. ^[27] Medical Genetics Unit, St George's, University of London, London, UK. ^[28] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.;Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. ^[29] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. aca20@medschl.cam.ac.uk. ^[30]

关键词 BRCA1/BRCA2 breast cancer ovarian cancer predictive test negatives risks