GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.-论文-万方医学网

第一作者： Lara,Gharibeh

第一单位： Department of Biochemistry, Microbiology, and Immunology, Molecular Genetics and Cardiac Regeneration Laboratory, University of Ottawa, Ontario, Canada (L.G., H.K., R.H., M.T., M.N.).

作者： Lara,Gharibeh ^[1] ; Hiba,Komati ^[1] ; Yohan,Bossé ^[2] ; Munir,Boodhwani ^[3] ; Mahyar,Heydarpour ^[1] ; Megan,Fortier ^[4] ; Romina,Hassanzadeh ^[3] ; Janet,Ngu ^[2] ; Patrick,Mathieu ^[4] ; Simon,Body ^[1] ; Mona,Nemer ; Bicuspid Aortic Valve Consortium

作者单位： Department of Biochemistry, Microbiology, and Immunology, Molecular Genetics and Cardiac Regeneration Laboratory, University of Ottawa, Ontario, Canada (L.G., H.K., R.H., M.T., M.N.). ^[1] Department of Molecular Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Canada (Y.B., P.M.). ^[2] Division of Cardiac Surgery, University of Ottawa Heart Institute, Ontario, Canada (M.B., J.N.). ^[3] Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (M.H., S.B.). ^[4]

医学主题词动物(Animals);主动脉瓣(Aortic Valve);病例对照研究(Case-Control Studies);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);细胞外基质(Extracellular Matrix);女(雌)性(Female);GATA6转录因子(GATA6 Transcription Factor);疾病遗传易感性(Genetic Predisposition to Disease);单倍剂量不足(Haploinsufficiency);心脏瓣膜疾病(Heart Valve Diseases);杂合子(Heterozygote);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);表型(Phenotype);信号传导(Signal Transduction);转录因子(Transcription Factors);Wnt1蛋白质(Wnt1 Protein)

DOI 10.1161/CIRCULATIONAHA.117.029506

PMID 29567669

发布时间 2020-12-18

检索历史清除

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

Circulation

相似文献

同项目论文

Circulation

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

Circulation

相似文献

同项目论文

Circulation

相关期刊

检索历史清除