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Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13.

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第一作者： Marion,David

第一单位： INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France; Institute of Parasitology, McGill University, Sainte-Anne-De-Bellevue, Canada.

作者： Marion,David ^[1] ; Chantal,Lebrun ^[2] ; Thomas,Duguet ^[3] ; Franck,Talmont ^[4] ; Robin,Beech ^[3] ; Stéphane,Orlowski ^[5] ; François,André ^[5] ; Roger K,Prichard ^[6] ; Anne,Lespine ^[7]

作者单位： INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France; Institute of Parasitology, McGill University, Sainte-Anne-De-Bellevue, Canada. ^[1] INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France. ^[2] Institute of Parasitology, McGill University, Sainte-Anne-De-Bellevue, Canada. ^[3] Institute of Pharmacology and Structural Biology, UMR 5089, CNRS, Toulouse, France. ^[4] CEA, Institut de Biologie Frédéric Joliot, Centre de Saclay, SB2SM, UMR9198 CNRS, I2BC; 91191 Gif-sur-Yvette Cedex, France. ^[5] Institute of Parasitology, McGill University, Sainte-Anne-De-Bellevue, Canada. Electronic address: roger.prichard@mcgill.ca. ^[6] INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France. Electronic address: anne.lespine@inra.fr. ^[7]

关键词 ABC transporters Haemonchus contortus Homology modeling Ivermectin Nematode P-glycoprotein