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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer.

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作者单位: Department of Molecular & Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [1] Verna & Marrs McLean Department of Biochemistry & Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [2] Interdepartmental Program in Molecular and Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [3] Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [4] Department of Physiology, Shandong University School of Medicine, Jinan, Shandong, China. [5] Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [6] Division of Biostatistics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [7] Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [8] Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [9] Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA. [10] Therapeutic Innovation Center, Baylor College of Medicine, Houston, Texas, USA. [11] Department of Molecular Biology and Biochemistry, Shandong University School of Medicine, Jinan, Shandong, China. [12] Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA. [13] Oncology Research Unit, Pfizer Global Research and Development, La Jolla, San Diego, California, USA. [14]
DOI 10.1038/nm.4507
PMID 29578538
发布时间 2024-06-07
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