Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).

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作者： Li,Zhong ^[1] ; Zongqi,Wang ^[1] ; Daxin,Wang ^[1] ; Zhe,Wang ^[1] ; Yuka A,Martens ^[2] ; Linbei,Wu ^[1] ; Ying,Xu ^[1] ; Kai,Wang ^[1] ; Jianguo,Li ^[1] ; Ruizhi,Huang ^[1] ; Dan,Can ^[1] ; Huaxi,Xu ^[3] ; Guojun,Bu ^[4] ; Xiao-Fen,Chen ^[5]

作者单位： Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China. ^[1] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. ^[2] Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China.;Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, 92037, USA. ^[3] Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China. bu.guojun@mayo.edu.;Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, USA. bu.guojun@mayo.edu. ^[4] Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, 361102, China. chenxf@xmu.edu.cn.;Shenzhen Research Institute of Xiamen University, Shenzhen, 518063, China. chenxf@xmu.edu.cn. ^[5]

关键词 Alzheimer’s disease TREM2 microglia migration β-amyloid