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Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.

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作者单位: Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America. [1] Division of Hematology/Oncology, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America. [2] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America. [3] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America. [4] Hematology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America. [5] Department of Medicine, Université de Montréal, Montréal, Quebec, Canada. [6] Montreal Heart Institute, Montréal, Quebec, Canada. [7] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America. [8] Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. [9] Department of Biostatistics, University of Washington, Seattle, Washington, United States of America. [10] Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America. [11] Department of Laboratory Medicine & Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America. [12] Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, United States of America. [13] Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America. [14] Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America. [15] Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, United States of America. [16] Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina, United States of America. [17] Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, United States of America. [18] Seattle Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America. [19] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America. [20] Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. [21] Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America. [22] Department of Epidemiology, University of Washington, Seattle, Washington, United States of America. [23]
DOI 10.1371/journal.pgen.1007293
PMID 29590102
发布时间 2024-03-14
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