Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites.

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作者： Denis S,Kudryavtsev ^[1] ; Ekaterina N,Spirova ^[2] ; Irina V,Shelukhina ^[3] ; Lina V,Son ^[4] ; Yana V,Makarova ^[5] ; Natalia K,Utkina ^[6] ; Igor E,Kasheverov ^[7] ; Victor I,Tsetlin ^[8]

作者单位： Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. kudryavtsev@ibch.ru. ^[1] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. katya_spirova@mail.ru. ^[2] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. shelukhina.iv@yandex.ru. ^[3] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. lina.son@phystech.edu. ^[4] Moscow Institute of Physics and Technology, Institutsky Per. 9, Dolgoprudny, 141700 Moscow Region, Russia. lina.son@phystech.edu. ^[5] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. yanson1@yandex.ru. ^[6] G.B. Elyakov Pacific Institute of Bioorganic Chemistry (PIBOC), Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, 690022 Vladivostok, Russia. utkinan@mail.ru. ^[7] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. iekash@ibch.ru. ^[8] Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia. vits@ibch.ru. ^[9]

关键词 marine natural products myasthenic nicotinic receptors slow-channel