Calculated cell-specific intracellular hydrogen peroxide concentration: Relevance in cancer cell susceptibility during ascorbate therapy.

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作者： Dieanira,Erudaitius ^[1] ; Jacqueline,Mantooth ^[1] ; Andrew,Huang ^[2] ; Jesse,Soliman ^[1] ; Claire M,Doskey ^[3] ; Garry R,Buettner ^[4] ; Victor G J,Rodgers ^[5]

作者单位： Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA. ^[1] Department of Neuroscience, University of California, Riverside, Riverside, CA 92521, USA. ^[2] Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48823, USA. ^[3] Free Radical & Radiation Biology, Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, IA 52242, USA. ^[4] Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: victor.rodgers@ucr.edu. ^[5]

关键词 Catalase Cytosol Hydrogen peroxide Intracellular hydrogen peroxide concentration Mathematical model Parameter sensitivity Peroxisome permeability Pharmacological ascorbate therapy Plasma membrane permeability Transport properties of cells

主题词抗肿瘤药(Antineoplastic Agents);抗坏血酸(Ascorbic Acid);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);过氧化氢(Hydrogen Peroxide);模型, 理论(Models, Theoretical)

DOI 10.1016/j.freeradbiomed.2018.03.044

PMID 29601946

发布时间 2023-11-03

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