Skeletal Optimization of Cytotoxic Lipidic Dialkynylcarbinols.

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作者： Maroua,Bourkhis ^[1] ; Hafida,Gaspard ^[2] ; Pauline,Rullière ^[1] ; Diana K C,de Almeida ^[1] ; Dymytrii,Listunov ^[3] ; Etienne,Joly ^[1] ; Raoudha,Abderrahim ^[4] ; Marcos C,de Mattos ^[5] ; Maria C F,de Oliveira ^[2] ; Valérie,Maraval ^[3] ; Remi,Chauvin ^[3] ; Yves,Génisson ^[4]

作者单位： SPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118 route de Narbonne, 31062, Toulouse Cedex 9, France. ^[1] 05/UR/13-01, LPMLNMH, Carthage University, Faculty of Sciences of Bizerte, 7021, Jarzouna, Tunisia. ^[2] Laboratory of Biotechnology and Organic Synthesis, Federal University of Ceará, Campus do Pici, Fortaleza, Ceará, Brazil. ^[3] LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France. ^[4] Institute of Pharmacology and Structural Biology, UMR5089 CNRS/UPS, Department of Structural Biology and Biophysics, Université Paul Sabatier-Toulouse III, 205 route de Narbonne, 31077, Toulouse Cedex 4, France. ^[5]

关键词 alkynols asymmetric synthesis cytotoxicity enzymatic kinetic resolution marine lipids polyacetylenes

主题词炔类(Alkynes);抗肿瘤药(Antineoplastic Agents);脂肪族醇类(Fatty Alcohols);HCT116细胞(HCT116 Cells);人类(Humans);分子结构(Molecular Structure);立体异构现象(Stereoisomerism)

DOI 10.1002/cmdc.201800118

PMID 29603643

发布时间 2019-06-24

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