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Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

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作者单位: Evolution and Cancer Laboratory, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [1] Centre for Maths and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK. [2] Department of Computer Science, University College London, London, UK. [3] Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands. [4] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [5] KU Leuven (University of Leuven), University Hospitals Leuven, Department of Obstetrics and Gynaecology, Division of Gynaecological Oncology, Leuven, Belgium. [6] KU Leuven, Department of Human Genetics, Laboratory for Translational Genetics, Leuven, Belgium. [7] VIB Centre for Cancer Biology, Laboratory for Translational Genetics, Leuven, Belgium. [8] Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. [9] Department of Cell and Developmental Biology, University College London, London, UK. [10] MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. [11] Department of Oncology, University of Oxford, Oxford, UK. [12] Ovarian Cancer Cell Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. [13] Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK. [14] Centre for Gynaecological Oncology Amsterdam, Netherlands Cancer Institute, Amsterdam, The Netherlands. [15]
DOI 10.1002/path.5081
PMID 29604063
发布时间 2024-06-04
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