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Divergence in DNA Specificity among Paralogous Transcription Factors Contributes to Their Differential In Vivo Binding.

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第一作者： Ning,Shen

第一单位： Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA.

作者： Ning,Shen ^[1] ; Jingkang,Zhao ^[2] ; Joshua L,Schipper ^[3] ; Yuning,Zhang ^[4] ; Tristan,Bepler ^[5] ; Dan,Leehr ^[5] ; John,Bradley ^[5] ; John,Horton ^[3] ; Hilmar,Lapp ^[5] ; Raluca,Gordan ^[6]

作者单位： Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA. ^[1] Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA. ^[2] Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA. ^[3] Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA. ^[4] Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA. ^[5] Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27710, USA; Department of Computer Science, Duke University, Durham, NC 27708, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA. Electronic address: raluca.gordan@duke.edu. ^[6]

关键词 E2F ETS RUNX bHLH differential protein-DNA binding divergence in DNA specificity genetic variation iMADS paralogous transcription factors

医学主题词结合部位(Binding Sites);基因表达调控(Gene Expression Regulation);模型, 遗传学(Models, Genetic);模型, 分子(Models, Molecular);序列分析, 蛋白质(Sequence Analysis, Protein);转录因子(Transcription Factors)

DOI 10.1016/j.cels.2018.02.009

PMID 29605182

发布时间 2021-01-09

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