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首页> Toxicology in vitro : an international journal published in association with BIBRA> Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.

Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis.

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作者： Friederike A,Sandbaumhüter ^[1] ; Sara,Vimercati ^[2] ; Wolfgang,Thormann ^[1] ; Meike,Mevissen ^[3]

作者单位： Clinical Pharmacology Laboratory, Institute for Infectious Diseases, University of Bern, Murtenstrasse 35, Bern 3008, Switzerland. ^[1] Veterinary Pharmacology and Toxicology, Department of Clinical research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Länggassstrasse 124, Bern 3012, Switzerland. ^[2] Veterinary Pharmacology and Toxicology, Department of Clinical research and Veterinary Public Health, Vetsuisse Faculty, University of Bern, Länggassstrasse 124, Bern 3012, Switzerland. Electronic address: meike.mevissen@vetsuisse.unibe.ch. ^[3]

关键词 Capillary electrophoresis Drug-drug interactions Equine cytochrome P450 enzymes Ketamine Metabolism

主题词麻醉药, 离解(Anesthetics, Dissociative);动物(Animals);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);地西泮(Diazepam);药物相互作用(Drug Interactions);电泳, 毛细管(Electrophoresis, Capillary);马(Horses);氯胺酮(Ketamine);美托咪啶(Medetomidine);美沙酮(Methadone);微粒体, 肝(Microsomes, Liver);立体异构现象(Stereoisomerism)

DOI 10.1016/j.tiv.2018.03.016

PMID 29614330

发布时间 2018-10-15

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Toxicology in vitro

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Toxicology in vitro

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