Physical Origin of Thermostabilization by a Quadruple Mutation for the Adenosine A<sub>2a</sub> Receptor in the Active State.

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作者： Yuta,Kajiwara ^[1] ; Satoshi,Yasuda ^[2] ; Simon,Hikiri ^[3] ; Tomohiko,Hayashi ^[4] ; Mitsunori,Ikeguchi ^[2] ; Takeshi,Murata ^[4] ; Masahiro,Kinoshita ^[4]

作者单位： Graduate School of Energy Science , Kyoto University , Uji, Kyoto 611-0011 , Japan. ^[1] Graduate School of Science , Chiba University , 1-33 Yayoi-cho , Inage, Chiba 263-8522 , Japan. ^[2] Molecular Chirality Research Center , Chiba University , 1-33 Yayoi-cho , Inage, Chiba 263-8522 , Japan. ^[3] Institute of Advanced Energy , Kyoto University , Uji, Kyoto 611-0011 , Japan. ^[4] Graduate School of Medical Life Science , Yokohama City University , 1-7-29 Suehiro-cho , Tsurumi-ku, Yokohama 230-0045 , Japan. ^[5] RIKEN Medical Sciences Innovation Hub Program , 1-7-22 Suehiro-cho , Tsurumi-ku, Yokohama 230-0045 , Japan. ^[6] JST, PRESTO , 1-33 Yayoi-cho , Inage, Chiba 263-8522 , Japan. ^[7]

主题词分子动力学模拟(Molecular Dynamics Simulation);突变(Mutation);蛋白质稳定性(Protein Stability);受体, 腺苷A2A(Receptor, Adenosine A2A);热力学(Thermodynamics)

DOI 10.1021/acs.jpcb.8b00443

PMID 29617137

发布时间 2018-05-18

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