Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.-论文-万方医学网

第一作者： Patrik,Johansson

第一单位： Discovery Sciences, IMED Biotech Unit , AstraZeneca , S-43183 Mölndal , Sweden.

作者： Patrik,Johansson ^[1] ; Karin,Kaspersson ^[1] ; Ian K,Gurrell ^[2] ; Elisabeth,Bäck ^[1] ; Susanna,Eketjäll ^[3] ; Clay W,Scott ^[4] ; Gvido,Cebers ^[2] ; Philip,Thorne ^[5] ; Michael J,McKenzie ^[5] ; Haydn,Beaton ^[5] ; Paul,Davey ^[6] ; Karin,Kolmodin ^[7] ; Jörg,Holenz ^[2] ; Mark E,Duggan ^[2] ; Samantha,Budd Haeberlein ^[2] ; Roland W,Bürli ^[2]

作者单位： Discovery Sciences, IMED Biotech Unit , AstraZeneca , S-43183 Mölndal , Sweden. ^[1] Neuroscience, IMED Biotech Unit , AstraZeneca , Cambridge CB21 6GH , U.K. ^[2] Cardiovascular and Metabolic Diseases, IMED Biotech Unit , AstraZeneca , 141 57 Huddinge , Sweden. ^[3] Discovery Safety, Drug Safety and Metabolism, IMED Biotech Unit , AstraZeneca , Waltham , Massachusetts 02451 , United States. ^[4] Charnwood Molecular , Loughborough LE11 5DA , U.K. ^[5] Oncology Chemistry, IMED Biotech Unit , AstraZeneca , Cambridge CB4 0WG , U.K. ^[6] Sprint Bioscience , 141 57 Huddinge , Sweden. ^[7]

主题词淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);脑(Brain);催化域(Catalytic Domain);狗(Dogs);女(雌)性(Female);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);分子结构(Molecular Structure);恶唑类(Oxazoles);肽碎片(Peptide Fragments);蛋白酶抑制药(Protease Inhibitors);蛋白质亚型(Protein Isoforms);大鼠(Rats);螺环化合物(Spiro Compounds);构效关系(Structure-Activity Relationship);gp100黑色素瘤抗原(gp100 Melanoma Antigen)

DOI 10.1021/acs.jmedchem.7b01716

PMID 29617572

发布时间 2019-04-23

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Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity.

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

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