Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

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作者： Keisuke,Watanabe ^[1] ; Yanping,Luo ^[1] ; Tong,Da ^[1] ; Sonia,Guedan ^[1] ; Marco,Ruella ^[2] ; John,Scholler ^[1] ; Brian,Keith ^[2] ; Regina M,Young ^[1] ; Boris,Engels ^[1] ; Suvi,Sorsa ^[3] ; Mikko,Siurala ^[1] ; Riikka,Havunen ^[4] ; Siri,Tähtinen ^[5] ; Akseli,Hemminki ^[6] ; Carl H,June ^[5]

作者单位： Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[1] Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[2] The Wistar Institute, Philadelphia, Pennsylvania, USA. ^[3] Department of Immuno-Oncology, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA. ^[4] Cancer Gene Therapy Group, Faculty of Medicine, University of Helsinki, Helsinki, Finland. ^[5] TILT Biotherapeutics Ltd, Helsinki, Finland. ^[6] Helsinki University Comprehensive Cancer Center, Helsinki, Finland. ^[7] Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[8]

关键词 Cancer Cancer gene therapy T cells Therapeutics

主题词腺病毒科(Adenoviridae);动物(Animals);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);综合疗法(Combined Modality Therapy);GPI连接蛋白质类(GPI-Linked Proteins);人类(Humans);免疫疗法, 过继(Immunotherapy, Adoptive);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);小鼠(Mice);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses);胰腺肿瘤(Pancreatic Neoplasms);T淋巴细胞(T-Lymphocytes);肿瘤微环境(Tumor Microenvironment);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1172/jci.insight.99573

PMID 29618658

发布时间 2023-08-17

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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

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Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

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