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Integrating images from multiple microscopy screens reveals diverse patterns of change in the subcellular localization of proteins.

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第一作者： Alex X,Lu

第一单位： Department of Computer Science, University of Toronto, Toronto, Canada.

作者： Alex X,Lu ^[1] ; Yolanda T,Chong ^[2] ; Ian Shen,Hsu ^[3] ; Bob,Strome ^[3] ; Louis-Francois,Handfield ^[1] ; Oren,Kraus ^[4] ; Brenda J,Andrews ^[5] ; Alan M,Moses ^[6]

作者单位： Department of Computer Science, University of Toronto, Toronto, Canada. ^[1] Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada. ^[2] Department of Cell and Systems Biology, University of Toronto, Toronto, Canada. ^[3] Department of Electrical and Computer Engineering, University of Toronto, Toronto, Canada. ^[4] Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, Canada. ^[5] Department of Computer Science, University of Toronto, Toronto, Canada.;Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.;Center for Analysis of Genome Evolution and Function, University of Toronto, Toronto, Canada. ^[6]

关键词 S. cerevisiae bioimage informatics cell biology computational biology fluorescence microscopy image analysis proteomics systems biology unsupervised machine leaning