Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice.

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第一作者： Yuji,Teraoka

第一单位： Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan.

作者： Yuji,Teraoka ^[1] ; Takuro,Uchida ^[1] ; Michio,Imamura ^[1] ; Mitsutaka,Osawa ^[1] ; Masataka,Tsuge ^[2] ; Hiromi,Abe-Chayama ^[3] ; C Nelson,Hayes ^[1] ; Grace Naswa,Makokha ^[1] ; Hiroshi,Aikata ^[1] ; Daiki,Miki ^[4] ; Hidenori,Ochi ^[4] ; Yuji,Ishida ^[5] ; Chise,Tateno ^[5] ; Kazuaki,Chayama ^[6] ; Hiroshima Liver Study Group

作者单位： Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan. ^[1] Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan; Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan. ^[2] Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan; Center for Medical Specialist Graduate Education and Research, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. ^[3] Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan. ^[4] Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan; PhoenixBio Co., Ltd., Higashihiroshima, Japan. ^[5] Department of Gastroenterology and Metabolism, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan; Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan. Electronic address: chayama@hiroshima-u.ac.jp. ^[6]

关键词 Glecaprevir HCV Human hepatocyte chimeric mouse NS5A inhibitor resistance associated variant P32 deletion Pibrentasvir Sofosbuvir