Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer.-论文-万方医学网

第一作者： Jenna H,Newman

第一单位： Section of Surgical Oncology Research, Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA.

作者： Jenna H,Newman ^[1] ; David J,Augeri ^[2] ; Rachel,NeMoyer ^[3] ; Jyoti,Malhotra ^[4] ; Elaine,Langenfeld ^[5] ; Charles B,Chesson ^[1] ; Natalie S,Dobias ^[1] ; Michael J,Lee ^[3] ; Saeed,Tarabichi ^[3] ; Sachin R,Jhawar ^[6] ; Praveen K,Bommareddy ^[1] ; Sh'Rae,Marshall ^[1] ; Evita T,Sadimin ^[7] ; John E,Kerrigan ^[8] ; Michael,Goedken ^[9] ; Christine,Minerowicz ^[7] ; Salma K,Jabbour ^[6] ; Shengguo,Li ^[1] ; Mary O,Carayannopolous ^[7] ; Andrew,Zloza ^[10] ; John,Langenfeld ^[11]

作者单位： Section of Surgical Oncology Research, Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. ^[1] Office of Translational Science, Molecular Design and Synthesis, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. ^[2] Department of Surgery, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08903, USA. ^[3] Division of Medical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. ^[4] Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. ^[5] Department of Radiation Oncology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA. ^[6] Department of Pathology and Laboratory Science, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08903, USA. ^[7] Department of Bioinformatics, Rutgers Biomedical Health Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. ^[8] Office of Translational Science, Research Pathology Services, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. ^[9] Section of Surgical Oncology Research, Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. andrew.zloza@rutgers.edu.;Department of Surgery, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, 08903, USA. andrew.zloza@rutgers.edu. ^[10] Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903, USA. langenje@cinj.rutgers.edu. ^[11]

主题词过继转移(Adoptive Transfer);动物(Animals);抗肿瘤药(Antineoplastic Agents);骨形态发生蛋白受体(Bone Morphogenetic Protein Receptors);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞系, 肿瘤(Cell Line, Tumor);细胞存活(Cell Survival);人类(Humans);分化抑制蛋白1(Inhibitor of Differentiation Protein 1);肺肿瘤(Lung Neoplasms);MAP激酶激酶激酶类(MAP Kinase Kinase Kinases);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);蛋白激酶抑制剂(Protein Kinase Inhibitors);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);喹诺酮类(Quinolones);信号传导(Signal Transduction);肿瘤微环境(Tumor Microenvironment);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41388-018-0156-9

PMID 29622797

发布时间 2024-03-03

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Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer.

Oncogene

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Oncogene

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Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer.

Oncogene

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Oncogene

相关期刊

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