Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
第一作者:
Xiaohai,Wang
第一单位:
Merck Research Laboratories, West Point, Pennsylvania, United States of America.
作者:
医学主题词
动物(Animals);脑(Brain);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);多西环素(Doxycycline);酶抑制剂(Enzyme Inhibitors);基因表达(Gene Expression);人类(Humans);小鼠(Mice);小鼠, 129系(Mice, 129 Strain);小鼠, 转基因(Mice, Transgenic);运动活动(Motor Activity);突变蛋白质类(Mutant Proteins);神经原纤维缠结(Neurofibrillary Tangles);磷酰化(Phosphorylation);吡喃类(Pyrans);重组蛋白质类(Recombinant Proteins);Tau病变(Tauopathies);噻唑类(Thiazoles);β-N-乙酰氨基己糖苷酶类(beta-N-Acetylhexosaminidases);tau蛋白质类(tau Proteins)
DOI
10.1371/journal.pone.0195486
PMID
29624602
发布时间
2018-11-14
- 浏览13
PloS one
e0195486页
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