HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis.

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作者： Shijun,Wang ^[1] ; Jian,Wu ^[2] ; Jieyun,You ^[3] ; Hongyu,Shi ^[4] ; Xiaoyu,Xue ^[5] ; Jiayuan,Huang ^[2] ; Lei,Xu ^[2] ; Guoliang,Jiang ^[2] ; Lingyan,Yuan ^[6] ; Xue,Gong ^[7] ; Haiyan,Luo ^[2] ; Junbo,Ge ^[2] ; Zhaoqiang,Cui ^[8] ; Yunzeng,Zou ^[9]

作者单位： Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China. Electronic address: wang.shijun@zs-hospital.sh.cn. ^[1] Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China. ^[2] Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China. ^[3] Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiaotong University, 241 West Huaihai Road, Shanghai 200030, China. ^[4] Department of Radiology, Yangpu Hospital Affiliated to Tongji University, 450 Tengyue Road, Shanghai 200090, China. ^[5] Shanghai Normal University, Guilin Road 100, Shanghai 200234, China. ^[6] Department of cardiology, Deltahealth Hospital, 109 Xule Road, Shanghai 201702, China. ^[7] Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China. Electronic address: cui.zhaoqiang@zs-hospital.sh.cn. ^[8] Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai 200032, China. Electronic address: zou.yunzeng@zs-hospital.sh.cn. ^[9]

关键词 AMPKα2 Cardiac angiogenesis HSF1 Pressure overload miR-195a-3p