首页> Cell chemical biology> Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

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第一作者： Malvika,Koundinya

第一单位： Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA.

作者： Malvika,Koundinya ^[1] ; Judith,Sudhalter ^[1] ; Albane,Courjaud ^[2] ; Bruno,Lionne ^[2] ; Gaetan,Touyer ^[2] ; Luc,Bonnet ^[2] ; Isabelle,Menguy ^[2] ; Isabelle,Schreiber ^[2] ; Christelle,Perrault ^[2] ; Stephanie,Vougier ^[2] ; Brigitte,Benhamou ^[2] ; Bailin,Zhang ^[3] ; Timothy,He ^[3] ; Qiang,Gao ^[3] ; Patricia,Gee ^[3] ; Daniel,Simard ^[4] ; M Paola,Castaldi ^[5] ; Ronald,Tomlinson ^[5] ; Stephan,Reiling ^[6] ; Matthieu,Barrague ^[7] ; Richard,Newcombe ^[1] ; Hui,Cao ^[8] ; Yanjun,Wang ^[9] ; Fangxian,Sun ^[9] ; Joshua,Murtie ^[9] ; Mark,Munson ^[7] ; Eric,Yang ^[8] ; David,Harper ^[1] ; Monsif,Bouaboula ^[1] ; Jack,Pollard ^[8] ; Claudine,Grepin ^[2] ; Carlos,Garcia-Echeverria ^[3] ; Hong,Cheng ^[3] ; Francisco,Adrian ^[1] ; Christopher,Winter ^[1] ; Stuart,Licht ^[10] ; Ivan,Cornella-Taracido ^[5] ; Rosalia,Arrebola ^[2] ; Aaron,Morris ^[11]

作者单位： Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[1] LGCR-LIT, Sanofi, Vitry-Sur-Seine 94400, France. ^[2] Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[3] Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA; Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[4] Chemistry, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[5] LGCR-SDI, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[6] LGCR, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[7] TEM-BioInformatics, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[8] In Vivo Pharmacology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. ^[9] Biochemistry, Bioanalytics, and Chemical Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: sslicht@gmail.com. ^[10] Cancer Biology, Oncology Division, Sanofi, Cambridge, MA 02138, USA. Electronic address: aaronjmorris@gmail.com. ^[11]

关键词 KRAS mutation cancer metabolism chemoproteomics pyrimidine biosynthesis synthetic lethality