Antimicrobial agent triclosan disrupts mitochondrial structure, revealed by super-resolution microscopy, and inhibits mast cell signaling via calcium modulation.

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作者： Lisa M,Weatherly ^[1] ; Andrew J,Nelson ^[2] ; Juyoung,Shim ^[3] ; Abigail M,Riitano ^[3] ; Erik D,Gerson ^[3] ; Andrew J,Hart ^[3] ; Jaime,de Juan-Sanz ^[4] ; Timothy A,Ryan ^[4] ; Roger,Sher ^[5] ; Samuel T,Hess ^[6] ; Julie A,Gosse ^[7]

作者单位： Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA. ^[1] Department of Physics and Astronomy, University of Maine, Orono, ME, USA. ^[2] Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA. ^[3] Department of Biochemistry, Weill Cornell Medicine, New York, NY, USA. ^[4] Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, USA. ^[5] Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA; Department of Physics and Astronomy, University of Maine, Orono, ME, USA. Electronic address: Samuel.hess@maine.edu. ^[6] Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, USA; Department of Molecular and Biomedical Sciences, University of Maine, Orono, ME, USA. Electronic address: Julie.gosse@maine.edu. ^[7]

关键词 Ca(2+)Degranulation Fluorescence photoactivation localization microscopy (FPALM)Keratinocyte Mast cell Membrane potential Microtubules Mitochondria NIH-3T3 RBL-2H3 Reactive oxygen species Super-resolution microscopy Triclosan