首页> Oncoimmunology> Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression.

Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression.

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第一作者： Pilar M,Lanuza

第一单位： Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.

作者： Pilar M,Lanuza ^[1] ; Alan,Vigueras ^[2] ; Sara,Olivan ^[2] ; Anne C,Prats ^[3] ; Santiago,Costas ^[1] ; Guillermo,Llamazares ^[2] ; Diego,Sanchez-Martinez ^[1] ; José María,Ayuso ^[4] ; Luis,Fernandez ^[2] ; Ignacio,Ochoa ^[2] ; Julián,Pardo ^[5]

作者单位： Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain. ^[1] Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.;Group of Applied Mechanics and Bioengineering (AMB); Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza, Spain.;Centro Investigacion Biomedica en Red. Bioingenieria, biomateriales y nanomedicina (CIBER-BBN). ^[2] Inserm, U1037, F-31432 Toulouse, France, Université de Toulouse, UPS, Cancer Research Center of Toulouse, F-31432 Toulouse, France. ^[3] Medical Engineering, Morgridge Institute for Research, Madison, Wisconsin, USA.;Department of Biomedical Engineering, Wisconsin Institutes for Medical Research, University of Wisconsin, Madison, WI, USA.;The University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. ^[4] Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.;Dpt. Microbiology, Preventive Medicine and Public Health and Dpt. Biochemistry and Molecular and Cell Biology, University of Zaragoza, Zaragoza, Spain.;Aragón I+D Foundation (ARAID), Government of Aragon, Zaragoza, Spain Nanoscience Institute of Aragon (INA), University of Zaragoza, Zaragoza, Spain. ^[5]

关键词 3D Spheroids cultures Colorectal Carcinoma Immunotherapy Natural Killer Cells Activation allogeneic human primary Natural Killer Cells

DOI 10.1080/2162402X.2017.1395123

PMID 29632716

发布时间 2021-01-12

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