Increased formate overflow is a hallmark of oxidative cancer.-论文-万方医学网

作者： Johannes,Meiser ^[1] ; Anne,Schuster ^[2] ; Matthias,Pietzke ^[1] ; Johan,Vande Voorde ^[1] ; Dimitris,Athineos ^[1] ; Kristell,Oizel ^[1] ; Guillermo,Burgos-Barragan ^[3] ; Niek,Wit ^[3] ; Sandeep,Dhayade ^[1] ; Jennifer P,Morton ^[1] ; Emmanuel,Dornier ^[4] ; David,Sumpton ^[1] ; Gillian M,Mackay ^[1] ; Karen,Blyth ^[1] ; Ketan J,Patel ^[1] ; Simone P,Niclou ^[3] ; Alexei,Vazquez ^[5]

作者单位： Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK. ^[1] Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg Institute of Health, L-1526, Luxembourg, Luxembourg. ^[2] MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. ^[3] Institute for Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK. ^[4] Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 2QQ, UK. ^[5] Department of Biomedicine, Kristian Gerhard Jebsen Brain Tumour Research Center, University of Bergen, Bergen, N-5009, Norway. ^[6] Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK. a.vazquez@beatson.gla.ac.uk. ^[7] Institute for Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK. a.vazquez@beatson.gla.ac.uk. ^[8]

主题词腺瘤(Adenoma);动物(Animals);抗代谢药, 抗肿瘤(Antimetabolites, Antineoplastic);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);甲酸盐类(Formates);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);甘氨酸羟甲基转移酶(Glycine Hydroxymethyltransferase);肠黏膜(Intestinal Mucosa);肠肿瘤(Intestinal Neoplasms);肠(Intestines);同工酶类(Isoenzymes);男(雄)性(Male);乳腺, 动物(Mammary Glands, Animal);乳房肿瘤, 实验性(Mammary Neoplasms, Experimental);乳房瘤病毒, 鼠(Mammary Tumor Virus, Mouse);甲氨蝶呤(Methotrexate);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);线粒体(Mitochondria);氧化还原(Oxidation-Reduction);丝氨酸(Serine);肿瘤微环境(Tumor Microenvironment)

DOI 10.1038/s41467-018-03777-w

PMID 29636461

发布时间 2024-02-10

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Increased formate overflow is a hallmark of oxidative cancer.

Nature communications

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Increased formate overflow is a hallmark of oxidative cancer.

Nature communications

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Nature communications

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