Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β<sub>2</sub>AR-cAMP Responsiveness in Murine Hearts.-论文-万方医学网

第一作者： Peter T,Wright

第一单位： Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.

作者： Peter T,Wright ^[1] ; Navneet K,Bhogal ^[1] ; Ivan,Diakonov ^[1] ; Laura M K,Pannell ^[1] ; Ruwan K,Perera ^[2] ; Nadja I,Bork ^[2] ; Sophie,Schobesberger ^[3] ; Carla,Lucarelli ^[4] ; Giuseppe,Faggian ^[5] ; Anita,Alvarez-Laviada ^[1] ; Manuela,Zaccolo ^[6] ; Timothy J,Kamp ^[7] ; Ravi C,Balijepalli ^[7] ; Alexander R,Lyon ^[8] ; Sian E,Harding ^[1] ; Viacheslav O,Nikolaev ^[2] ; Julia,Gorelik ^[9]

作者单位： Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. ^[1] Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. ^[2] Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. ^[3] Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; Department of Cardiac Surgery, University of Verona School of Medicine, Azienda Ospedalieria Universitaria Integrata, Borgo Trento Piazzale A. Stefani, 37126 Verona, Italy. ^[4] Department of Cardiac Surgery, University of Verona School of Medicine, Azienda Ospedalieria Universitaria Integrata, Borgo Trento Piazzale A. Stefani, 37126 Verona, Italy. ^[5] Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK. ^[6] Department of Medicine, University of Wisconsin Madison, 1111 Highland Ave., Madison, WI 53705-2275, USA. ^[7] Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK; NIHR Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London SW7 3AZ, UK. ^[8] Myocardial Function, National Heart and Lung Institute, Imperial College London, ICTEM, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. Electronic address: j.gorelik@imperial.ac.uk. ^[9]

主题词肾上腺素能β-2受体激动剂(Adrenergic beta-2 Receptor Agonists);动物(Animals);窖蛋白3(Caveolin 3);细胞膜(Cell Membrane);胆固醇(Cholesterol);环AMP(Cyclic AMP);环核苷酸磷酸二酯酶类, 4型(Cyclic Nucleotide Phosphodiesterases, Type 4);女(雌)性(Female);心脏(Heart);异丙肾上腺素(Isoproterenol);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);肌收缩(Muscle Contraction);肌细胞, 心脏(Myocytes, Cardiac);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 肾上腺素能β2(Receptors, Adrenergic, beta-2);信号传导(Signal Transduction);β环糊精类(beta-Cyclodextrins)

DOI 10.1016/j.celrep.2018.03.053

PMID 29642004

发布时间 2022-04-05

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Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β<sub>2</sub>AR-cAMP Responsiveness in Murine Hearts.

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Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β<sub>2</sub>AR-cAMP Responsiveness in Murine Hearts.

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