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Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis.

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作者单位: Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Karim.Elkasmi@ucdenver.edu. [1] Pediatric Liver Center, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA. Karim.Elkasmi@ucdenver.edu. [2] Department of Immunology and Respiratory, Boehringer-Ingelheim Pharma GmbH &Co. KG, Birkendorferstrasse 65, 88397, Biberach an der Riss, Germany. Karim.Elkasmi@ucdenver.edu. [3] Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, 80045, USA. [4] Pediatric Liver Center, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA. [5] Department of Pediatrics, Providence Pediatric Gastroenterology, University of Washington, Anchorage, AK, 99515, USA. [6] Laboratory for Gastroenterology and Hepatology (GAEN), IREC, Universite Catholique de Louvain, Belgium 1, Place de l'Université, 1348, Louvain-la-Neuve, Belgium. [7] Cardiovascular Pulmonary Research and Division of Pediatric Critical Care, Department of Pediatrics, University of Colorado School of Medicine, 12800 East 19th Avenue, Aurora, CO, 80045, USA. [8] Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, 12800 East 19th Avenue, Aurora, CO, 80045, USA. [9] Department of Pathology, University of Colorado School of Medicine, Building RC-1, North Tower, 12800 East 19th Avenue, Aurora, CO, 80045, USA. [10] Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, 12801, E 17th Ave, Aurora, CO, 80045, USA. [11] Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Ronald.Sokol@childrenscolorado.org. [12] Pediatric Liver Center, Digestive Health Institute, Children's Hospital Colorado, Aurora, CO, 80045, USA. Ronald.Sokol@childrenscolorado.org. [13]
DOI 10.1038/s41467-018-03764-1
PMID 29643332
发布时间 2023-07-10
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