Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide.

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第一作者： Jens,Schumacher

第一单位： Biopharmaceutical New Technologies (BioNTech) Protein Therapeutics Corporation, An der Goldgrube 12, 55131, Mainz, Germany.;Department of Internal Medicine III, Translational and Experimental Oncology, University Medical Center of Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany.

作者： Jens,Schumacher ^[1] ; Tijana,Bacic ^[1] ; René,Staritzbichler ^[2] ; Matin,Daneschdar ^[3] ; Thorsten,Klamp ^[1] ; Philipp,Arnold ^[4] ; Sabrina,Jägle ^[1] ; Özlem,Türeci ^[5] ; Jürgen,Markl ^[6] ; Ugur,Sahin ^[7]

作者单位： Biopharmaceutical New Technologies (BioNTech) Protein Therapeutics Corporation, An der Goldgrube 12, 55131, Mainz, Germany.;Department of Internal Medicine III, Translational and Experimental Oncology, University Medical Center of Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany. ^[1] TRON Translational Oncology, University Medical Center of Johannes Gutenberg University, TRON gGmbH, Freiligrathstrasse 12, 55131, Mainz, Germany. ^[2] Department of Internal Medicine III, Translational and Experimental Oncology, University Medical Center of Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany. ^[3] Institute of Zoology, Johannes Gutenberg University, Johannes-von-Müller-Weg 6, 55128, Mainz, Germany.;Anatomical Institute, Otto-Hahn Platz 8, 24118, Kiel, Germany. ^[4] Ganymed Pharmaceuticals AG, An der Goldgrube 12, 55131, Mainz, Germany. ^[5] Institute of Zoology, Johannes Gutenberg University, Johannes-von-Müller-Weg 6, 55128, Mainz, Germany. ^[6] Biopharmaceutical New Technologies (BioNTech) Protein Therapeutics Corporation, An der Goldgrube 12, 55131, Mainz, Germany. sahin@uni-mainz.de.;Department of Internal Medicine III, Translational and Experimental Oncology, University Medical Center of Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany. sahin@uni-mainz.de.;TRON Translational Oncology, University Medical Center of Johannes Gutenberg University, TRON gGmbH, Freiligrathstrasse 12, 55131, Mainz, Germany. sahin@uni-mainz.de. ^[7]

关键词 Bioengineering Bionanoparticles Capsid and particle stability Chimeric VLP Computational biology Hepatitis B virus Molecular mechanism Structural biology Vaccine Virus-like-particles (VLP)