A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.

导出 LinkOut

翻译打印收藏纠错

作者： Blaine W,Phillips ^[1] ; Walter K,Schlage ^[2] ; Bjoern,Titz ^[3] ; Ulrike,Kogel ^[3] ; Davide,Sciuscio ^[3] ; Florian,Martin ^[3] ; Patrice,Leroy ^[3] ; Gregory,Vuillaume ^[3] ; Subash,Krishnan ^[1] ; Tom,Lee ^[1] ; Emilija,Veljkovic ^[1] ; Ashraf,Elamin ^[3] ; Celine,Merg ^[3] ; Nikolai V,Ivanov ^[3] ; Manuel C,Peitsch ^[3] ; Julia,Hoeng ^[3] ; Patrick,Vanscheeuwijck ^[4]

作者单位： PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore. ^[1] Biology Consultant, Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany. ^[2] PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland. ^[3] PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland. Electronic address: Patrick.Vanscheeuwijck@pmi.com. ^[4]

关键词 Adaptive airway changes Heat-not-burn technology Lung inflammation Modified risk tobacco product Systemic effects