Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases.

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第一作者： Dong,Zhang

作者： Dong,Zhang ; Marios S,Markoulides ; Dmitrijs,Stepanovs ; Anna M,Rydzik ; Ahmed,El-Hussein ; Corentin,Bon ; Jos J A G,Kamps ; Klaus-Daniel,Umland ; Patrick M,Collins ; Samuel T,Cahill ; David Y,Wang ; Frank,von Delft ; Jürgen,Brem ; Michael A,McDonough ; Christopher J,Schofield

关键词 Antibiotic resistance Carbapenemase Inhibitors Metallo β-lactamase Structure activity relationships

主题词烯二炔类(Enediynes);半数抑制浓度(Inhibitory Concentration 50);分子结构(Molecular Structure);绕丹宁(Rhodanine);构效关系(Structure-Activity Relationship);巯基化合物(Sulfhydryl Compounds);β-内酰胺酶类(beta-Lactamases)

DOI 10.1016/j.bmc.2018.02.043

PMID 29655609

发布时间 2024-08-21

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