Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.

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作者： Michael,Taschner ^[1] ; Anna,Lorentzen ^[1] ; André,Mourão ^[2] ; Toby,Collins ^[3] ; Grace M,Freke ^[3] ; Dale,Moulding ^[4] ; Jerome,Basquin ^[5] ; Dagan,Jenkins ^[3] ; Esben,Lorentzen ^[1]

作者单位： Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark. ^[1] Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany. ^[2] Genetics and Genomic Medicine, University College London, London, United Kingdom. ^[3] Developmental Biology and Cancer Programmes, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. ^[4] Department of Structural Cell Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany. ^[5]

关键词 Chlamydomonas reinhardtii Cilium IFT80 Intraflagelllar transport cell biology ciliopathies molecular biophysics mouse protein structure structural biology

主题词细菌蛋白质类(Bacterial Proteins);载体蛋白质类(Carrier Proteins);衣滴虫属(Chlamydomonas);纤毛(Cilia);结晶学, X线(Crystallography, X-Ray);移码突变(Frameshift Mutation);蛋白质多聚化(Protein Multimerization)

DOI 10.7554/eLife.33067

PMID 29658880

发布时间 2022-07-16

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