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Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation-negative early-onset and high-risk breast cancer patients.

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第一作者： Julia,Böck

第一单位： Institute of Human Genetics, University of Würzburg, Würzburg, Germany.

作者： Julia,Böck ^[1] ; Silke,Appenzeller ^[2] ; Larissa,Haertle ^[1] ; Tamara,Schneider ^[1] ; Andrea,Gehrig ^[1] ; Jörg,Schröder ^[1] ; Simone,Rost ^[1] ; Beat,Wolf ^[3] ; Claus R,Bartram ^[4] ; Christian,Sutter ^[4] ; Thomas,Haaf ^[1]

作者单位： Institute of Human Genetics, University of Würzburg, Würzburg, Germany. ^[1] Comprehensive Cancer Center, University Hospital, Würzburg, Germany. ^[2] University of Applied Sciences Western Switzerland, Fribourg, Switzerland.;Department of Bioinformatics, University of Würzburg, Würzburg, Germany. ^[3] Institute of Human Genetics, University Hospital, Heidelberg, Germany. ^[4]

关键词 allele methylation error breast cancer susceptibility gene deep bisulfite sequencing early onset breast cancer epimutation familial breast cancer single CpG hypermethylation tumor suppressor gene