Prenatal nicotine exposure intergenerationally programs imperfect articular cartilage via histone deacetylation through maternal lineage.-论文-万方医学网

第一作者： Zhe,Xie

第一单位： Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, 185 Donghu Road, Wuchang District, Wuhan 430071, China.

作者： Zhe,Xie ^[1] ; Zhe,Zhao ^[2] ; Xu,Yang ^[1] ; Linguo,Pei ^[3] ; Hanwen,Luo ^[2] ; Qubo,Ni ^[1] ; Bin,Li ^[2] ; Yongjian,Qi ^[1] ; Kai,Tie ^[1] ; Jacques,Magdalou ^[4] ; Liaobin,Chen ^[5] ; Hui,Wang ^[6]

作者单位： Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, 185 Donghu Road, Wuchang District, Wuhan 430071, China. ^[1] Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. ^[2] Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China. ^[3] UMR 7561CNRS, Université de Lorraine, Faculté de Médicine, Vandoeuvre-lès-Nancy, France. ^[4] Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, 185 Donghu Road, Wuchang District, Wuhan 430071, China. Electronic address: lbchen@whu.edu.cn. ^[5] Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Diseases, 185 Donghu Road, Wuchang District, Wuhan 430071, China. Electronic address: wanghui19@whu.edu.cn. ^[6]

主题词乙酰化作用(Acetylation);年龄因素(Age Factors);软骨蛋白聚糖类(Aggrecans);动物(Animals);软骨, 关节(Cartilage, Articular);细胞, 培养的(Cells, Cultured);软骨细胞(Chondrocytes);软骨发生(Chondrogenesis);胶原Ⅱ型(Collagen Type II);女(雌)性(Female);基因表达调控, 发育期(Gene Expression Regulation, Developmental);孕龄(Gestational Age);组蛋白类(Histones);男(雄)性(Male);尼古丁(Nicotine);烟碱激动剂(Nicotinic Agonists);妊娠(Pregnancy);产前暴露迟发效应(Prenatal Exposure Delayed Effects);大鼠, Wistar(Rats, Wistar);信号传导(Signal Transduction)

DOI 10.1016/j.taap.2018.03.018

PMID 29660438

发布时间 2022-01-15

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Prenatal nicotine exposure intergenerationally programs imperfect articular cartilage via histone deacetylation through maternal lineage.

Toxicology and applied pharmacology

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Toxicology and applied pharmacology

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Prenatal nicotine exposure intergenerationally programs imperfect articular cartilage via histone deacetylation through maternal lineage.

Toxicology and applied pharmacology

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Toxicology and applied pharmacology

相关期刊

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