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Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study.

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第一作者： J W,Miller

第一单位： Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Jeff.Miller@cchmc.org.

作者： J W,Miller ^[1] ; R,Balyan ^[2] ; M,Dong ^[3] ; M,Mahmoud ^[4] ; J E,Lam ^[4] ; J N,Pratap ^[4] ; J R,Paquin ^[4] ; B L,Li ^[5] ; J P,Spaeth ^[4] ; A,Vinks ^[6] ; A W,Loepke ^[7]

作者单位： Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: Jeff.Miller@cchmc.org. ^[1] Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[2] Department of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[3] Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. ^[4] Department of Anaesthesiology, Guangzhou Women and Children's Medical Center and Guangzhou Medical University, Guangzhou, China. ^[5] Department of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Paediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. ^[6] Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[7]

关键词 anaesthesia dexmedetomidine intranasal paediatrics pharmacokinetics