A new therapy prevents intellectual disability in mouse with phenylketonuria.

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作者： Tiziana,Pascucci ^[1] ; Luigia,Rossi ^[2] ; Marco,Colamartino ^[1] ; Claudia,Gabucci ^[3] ; Claudia,Carducci ^[4] ; Alessandro,Valzania ^[1] ; Valeria,Sasso ^[5] ; Noemi,Bigini ^[3] ; Francesca,Pierigè ^[3] ; Maria Teresa,Viscomi ^[5] ; Rossella,Ventura ^[1] ; Simona,Cabib ^[1] ; Mauro,Magnani ^[2] ; Stefano,Puglisi-Allegra ^[1] ; Vincenzo,Leuzzi ^[6]

作者单位： Department of Psychology and Centro "Daniel Bovet", Sapienza University, via dei Marsi 78, 00185 Rome, Italy; Fondazione Santa Lucia, IRCCS, via Ardeatina 306, 00142 Rome, Italy. ^[1] Department of Biomolecular Sciences, University of Urbino "Carlo Bo", via Saffi 2, 61029 Urbino (PU), Italy; EryDel SpA, via Sasso 36, 61029 Urbino (PU), Italy. ^[2] Department of Biomolecular Sciences, University of Urbino "Carlo Bo", via Saffi 2, 61029 Urbino (PU), Italy. ^[3] Department of Experimental Medicine, Sapienza University, viale del Policlinico 155, 00161 Rome, Italy. ^[4] Fondazione Santa Lucia, IRCCS, via Ardeatina 306, 00142 Rome, Italy. ^[5] Department of Human Neuroscience, Sapienza University of Rome, via dei Sabelli 108, 00185 Rome, Italy. Electronic address: vincenzo.leuzzi@uniroma1.it. ^[6]

关键词 Behavior and PKU Cognition and PKU Enzyme replacement therapy Erythrocytes as drug delivery system PKU mouse model Phenylalanine ammonia lyase