Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.-论文-万方医学网

第一作者： Nicola,Rath

第一单位： Cancer Research UK Beatson Institute, Glasgow, United Kingdom.

作者： Nicola,Rath ^[1] ; June,Munro ^[1] ; Marie Francene,Cutiongco ^[2] ; Alicja,Jagiełło ^[2] ; Nikolaj,Gadegaard ^[2] ; Lynn,McGarry ^[1] ; Mathieu,Unbekandt ^[1] ; Evdokia,Michalopoulou ^[1] ; Jurre J,Kamphorst ^[3] ; David,Sumpton ^[1] ; Gillian,Mackay ^[1] ; Claire,Vennin ^[4] ; Marina,Pajic ^[4] ; Paul,Timpson ^[4] ; Michael F,Olson ^[5]

作者单位： Cancer Research UK Beatson Institute, Glasgow, United Kingdom. ^[1] Division of Biomedical Engineering, School of Engineering, University of Glasgow, Glasgow, United Kingdom. ^[2] Cancer Research UK Beatson Institute, Glasgow, United Kingdom.;Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. ^[3] The Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Sydney, Australia.;St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Kensington, Australia. ^[4] Cancer Research UK Beatson Institute, Glasgow, United Kingdom. m.olson@beatson.gla.ac.uk.;Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. ^[5]

主题词 1-(5-异喹啉磺酰基)-2-甲基哌嗪(1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine);2-羟苯乙胺(2-Hydroxyphenethylamine);酰胺类(Amides);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);小鼠(Mice);肿瘤侵润(Neoplasm Invasiveness);胰腺肿瘤(Pancreatic Neoplasms);磷酰化(Phosphorylation);蛋白激酶抑制剂(Protein Kinase Inhibitors);吡唑类(Pyrazoles);吡啶类(Pyridines);信号传导(Signal Transduction);rho相关激酶类(rho-Associated Kinases)

DOI 10.1158/0008-5472.CAN-17-1339

PMID 29669760

发布时间 2024-02-10

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.

Cancer research

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.

Cancer research

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Cancer research

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