Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis.

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作者： Jocelyn M,Choo ^[1] ; Guy C J,Abell ^[2] ; Rachel,Thomson ^[2] ; Lucy,Morgan ^[3] ; Grant,Waterer ^[4] ; David L,Gordon ^[5] ; Steven L,Taylor ^[6] ; Lex E X,Leong ^[2] ; Steve L,Wesselingh ^[1] ; Lucy D,Burr ^[2] ; Geraint B,Rogers ^[1]

作者单位： Infection and Immunity, South Australia Health and Medical Research Institute, Adelaide, South Australia, Australia. ^[1] SAHMRI Microbiome Research Laboratory, Flinders University School of Medicine, Adelaide, South Australia, Australia. ^[2] Gallipoli Medical Research Centre, University of Queensland, Greenslopes Private Hospital, Brisbane, Australia. ^[3] Department of Respiratory Medicine, Concord Hospital Clinical School, University of Sydney, Sydney, New South Wales, Australia. ^[4] School of Medicine and Pharmacology Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia. ^[5] Department of Microbiology and Infectious Diseases, Flinders University, Adelaide, South Australia, Australia. ^[6] Immunity, Infection and Inflammation Program, Mater Research Institute, University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia. ^[7] Department of Respiratory Medicine, Mater Health Services, South Brisbane, Queensland, Australia. ^[8] Infection and Immunity, South Australia Health and Medical Research Institute, Adelaide, South Australia, Australia geraint.rogers@sahmri.com. ^[9]

关键词 antibiotic resistance bronchiectasis macrolide therapy oropharyngeal microbiome

主题词放线菌属(Actinomyces);成年人(Adult);老年人(Aged);抗菌药(Anti-Bacterial Agents);支气管扩张症(Bronchiectasis);囊性纤维化(Cystic Fibrosis);抗药性, 细菌(Drug Resistance, Bacterial);琥乙红霉素(Erythromycin Ethylsuccinate);女(雌)性(Female);副流感嗜血菌(Haemophilus parainfluenzae);人类(Humans);肺(Lung);男(雄)性(Male);中年人(Middle Aged);口咽(Oropharynx);RNA, 核糖体, 16S(RNA, Ribosomal, 16S);序列分析, DNA(Sequence Analysis, DNA);链球菌属(Streptococcus);时间因素(Time Factors)

DOI 10.1128/mSphere.00103-18

PMID 29669883

发布时间 2019-03-12

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Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis.

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Impact of Long-Term Erythromycin Therapy on the Oropharyngeal Microbiome and Resistance Gene Reservoir in Non-Cystic Fibrosis Bronchiectasis.

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