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Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms.

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第一作者： Kristoffer L,Egerod

第一单位： Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen, Denmark. Electronic address: Egerod@sund.ku.dk.

作者： Kristoffer L,Egerod ^[1] ; Natalia,Petersen ^[2] ; Pascal N,Timshel ^[3] ; Jens C,Rekling ^[4] ; Yibing,Wang ^[5] ; Qinghua,Liu ^[5] ; Thue W,Schwartz ^[2] ; Laurent,Gautron ^[6]

作者单位： Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen, Denmark. Electronic address: Egerod@sund.ku.dk. ^[1] Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, and Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen, Denmark. ^[2] Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genomics, Faculty of Health and Medical Sciences, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen, Denmark. ^[3] Department of Neuroscience, University of Copenhagen, Nørre Allé 14, 2200, Copenhagen, Denmark. ^[4] Department of Biochemistry, UT Southwestern Medical Center at Dallas, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. ^[5] Division of Hypothalamic Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. Electronic address: Laurent.gautron@UTSouthwestern.edu. ^[6]

关键词 G protein-coupled receptors GLP1R Gut hormones Gut-brain axis NTSR1 Vagal afferent nerves