Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.

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作者： Xian,Li ^[1] ; Soon Jin,Park ^[1] ; Fansi,Jin ^[1] ; Yifeng,Deng ^[1] ; Ju Hye,Yang ^[2] ; Jae-Hoon,Chang ^[1] ; Dong-Young,Kim ^[1] ; Jung-Ae,Kim ^[1] ; Youn Ju,Lee ^[3] ; Makoto,Murakami ^[4] ; Kun Ho,Son ^[5] ; Hyeun Wook,Chang ^[6]

作者单位： College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea. ^[1] Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea. ^[2] Department of Pharmacology, School of Medicine, Catholic University of Daegu, 33 Duryugongwon-ro 17-gil, Nam-gu, Daegu 42472, Republic of Korea. ^[3] Laboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Japan. ^[4] Andong National University, 1375 Byeongdong-ro, Andong-Si, Gyeongbuk 36729, Republic of Korea. Electronic address: sonkh@andong.ac.kr. ^[5] College of Pharmacy, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address: hwchang@ynu.ac.kr. ^[6]

关键词 AMPK Allergy Mast cells Sirt1 Tanshinone IIA

主题词腺苷酸激酶(Adenylate Kinase);过敏反应(Anaphylaxis);基因表达调控(Gene Expression Regulation);基因敲低技术(Gene Knockdown Techniques);人类(Humans);肥大细胞(Mast Cells);受体, IgE(Receptors, IgE);信号传导(Signal Transduction);抗衰老酶1(Sirtuin 1)

DOI 10.1016/j.bcp.2018.04.015

PMID 29674003

发布时间 2021-12-04

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Biochemical pharmacology

2018年152卷

362-372页

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Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.

Biochemical pharmacology

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Biochemical pharmacology

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Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway.

Biochemical pharmacology

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Biochemical pharmacology

相关期刊

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