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Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.

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第一作者： Mario,Hofweber

第一单位： Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany.

作者： Mario,Hofweber ^[1] ; Saskia,Hutten ^[2] ; Benjamin,Bourgeois ^[3] ; Emil,Spreitzer ^[3] ; Annika,Niedner-Boblenz ^[4] ; Martina,Schifferer ^[5] ; Marc-David,Ruepp ^[6] ; Mikael,Simons ^[5] ; Dierk,Niessing ^[7] ; Tobias,Madl ^[3] ; Dorothee,Dormann ^[8]

作者单位： Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany. ^[1] Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany. ^[2] Institute of Molecular Biology & Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria. ^[3] Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85763 Neuherberg, Germany. ^[4] Institute of Neuronal Cell Biology, Technical University of Munich, 80805 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy); 81377 Munich, Germany. ^[5] Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland. ^[6] Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85763 Neuherberg, Germany; Institute of Pharmaceutical Biotechnology, Ulm University, 89081 Ulm, Germany. ^[7] Biomedical Center (BMC), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University of Munich, 82152 Planegg-Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy); 81377 Munich, Germany. Electronic address: dorothee.dormann@med.uni-muenchen.de. ^[8]

关键词 ALS FTD Karyopherin-β2 (Kapβ2)Transportin (TNPO1)arginine methylation fused in sarcoma (FUS)neurodegeneration nuclear import phase separation stress granules