换一批
换一批Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents.
作者：
主题词
氨基酸类(Amino Acids);抗菌药(Anti-Bacterial Agents);催化域(Catalytic Domain);结晶学, X线(Crystallography, X-Ray);药物设计(Drug Design);酶测定(Enzyme Assays);叶酸拮抗剂(Folic Acid Antagonists);人类(Humans);氢键合(Hydrogen Bonding);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);分子结构(Molecular Structure);卡氏肺囊虫(Pneumocystis carinii);蛋白质结合(Protein Binding);嘧啶类(Pyrimidines);吡咯类(Pyrroles);序列同源性, 氨基酸(Sequence Homology, Amino Acid);种特异性(Species Specificity);四氢叶酸脱氢酶(Tetrahydrofolate Dehydrogenase)
DOI
10.1016/j.bmc.2018.04.032
PMID
29691153
发布时间
2019-05-15
- 浏览7
Bioorganic & medicinal chemistry
2640-2650页
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