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A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

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作者单位: Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, 4000, Liege, Belgium. M.Herfs@uliege.be. [1] Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, 4000, Liege, Belgium. [2] Department of Human Genetics, University Hospital Center of Liege, 4000, Liege, Belgium. [3] Metastasis Research Laboratory, GIGA-Cancer, University of Liege, 4000, Liege, Belgium. [4] Department of Medical Oncology, University Hospital Center of Liege, 4000, Liege, Belgium. [5] Laboratory of Human Genetics, GIGA-Cancer, University of Liege, 4000, Liege, Belgium. [6] Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. [7] Institute of Pathology, Lausanne University Hospital, University of Lausanne, 1011, Lausanne, Switzerland. [8] Department of Pathology, Besançon University Hospital, University of Bourgogne Franche-Comté, 25000, Besançon, France. [9] EA3181, University of Bourgogne Franche-Comté, LabEx LipSTIC ANR-11-LABX-0021, 25000, Besançon, France. [10] CNR Papillomavirus, Besançon University Hospital, 25000, Besançon, France. [11] Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University, Stanford, CA, 94304, USA. [12] Department of Gastroenterology, Besançon University Hospital, University of Bourgogne Franche-Comté, 25000, Besançon, France. [13] Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA. [14]
DOI 10.1038/s41416-018-0049-2
PMID 29700411
发布时间 2019-06-25
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