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An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.

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第一作者： Donna M,Werling

第一单位： Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.

作者： Donna M,Werling ^[1] ; Harrison,Brand ^[2] ; Joon-Yong,An ^[1] ; Matthew R,Stone ^[3] ; Lingxue,Zhu ^[4] ; Joseph T,Glessner ^[2] ; Ryan L,Collins ^[5] ; Shan,Dong ^[1] ; Ryan M,Layer ^[6] ; Eirene,Markenscoff-Papadimitriou ^[1] ; Andrew,Farrell ^[6] ; Grace B,Schwartz ^[1] ; Harold Z,Wang ^[3] ; Benjamin B,Currall ^[2] ; Xuefang,Zhao ^[2] ; Jeanselle,Dea ^[1] ; Clif,Duhn ^[1] ; Carolyn A,Erdman ^[1] ; Michael C,Gilson ^[1] ; Rachita,Yadav ^[2] ; Robert E,Handsaker ^[7] ; Seva,Kashin ^[7] ; Lambertus,Klei ^[8] ; Jeffrey D,Mandell ^[1] ; Tomasz J,Nowakowski ^[9] ; Yuwen,Liu ^[10] ; Sirisha,Pochareddy ^[11] ; Louw,Smith ^[1] ; Michael F,Walker ^[1] ; Matthew J,Waterman ^[12] ; Xin,He ^[10] ; Arnold R,Kriegstein ^[13] ; John L,Rubenstein ^[1] ; Nenad,Sestan ^[11] ; Steven A,McCarroll ^[7] ; Benjamin M,Neale ^[14] ; Hilary,Coon ^[15] ; A Jeremy,Willsey ^[16] ; Joseph D,Buxbaum ^[17] ; Mark J,Daly ^[14] ; Matthew W,State ^[1] ; Aaron R,Quinlan ^[18] ; Gabor T,Marth ^[6] ; Kathryn,Roeder ^[19] ; Bernie,Devlin ^[20] ; Michael E,Talkowski ^[21] ; Stephan J,Sanders ^[22]

作者单位： Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. ^[1] Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.;Department of Neurology, Harvard Medical School, Boston, MA, USA.;Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. ^[2] Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. ^[3] Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA. ^[4] Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.;Department of Neurology, Harvard Medical School, Boston, MA, USA.;Program in Bioinformatics and Integrative Genomics, Division of Medical Sciences, Harvard Medical School, Boston, MA, USA. ^[5] Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.;USTAR Center for Genetic Discovery, University of Utah School of Medicine, Salt Lake City, UT, USA. ^[6] Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.;Department of Genetics, Harvard Medical School, Boston, MA, USA. ^[7] Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ^[8] Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.;Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.;Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA. ^[9] Department of Human Genetics, University of Chicago, Chicago, IL, USA. ^[10] Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, USA. ^[11] Department of Biology, Eastern Nazarene College, Quincy, MA, USA. ^[12] Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. ^[13] Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.;Analytical and Translational Genetics Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[14] Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.;Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, USA. ^[15] Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.;Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. ^[16] Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[17] Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.;USTAR Center for Genetic Discovery, University of Utah School of Medicine, Salt Lake City, UT, USA.;Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, UT, USA. ^[18] Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA.;Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA. ^[19] Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. devlinbj@upmc.edu. ^[20] Center for Genomic Medicine and Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. talkowski@chgr.mgh.harvard.edu.;Department of Neurology, Harvard Medical School, Boston, MA, USA. talkowski@chgr.mgh.harvard.edu.;Program in Medical and Population Genetics and Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA. talkowski@chgr.mgh.harvard.edu.;Departments of Pathology and Psychiatry, Massachusetts General Hospital, Boston, MA, USA. talkowski@chgr.mgh.harvard.edu. ^[21] Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. stephan.sanders@ucsf.edu. ^[22]